Description

2-(4-n-Boc-Piperazin-1-Yl)Methylbenzoic Acid is a high-purity, protected piperazine derivative widely used as a critical building block in pharmaceutical research and development. This compound is essential for medicinal chemists designing and synthesizing novel drug candidates, particularly in areas requiring sophisticated molecular scaffolds. Its primary value lies in enabling the controlled introduction of the piperazine moiety, a privileged structure in drug discovery, into target molecules. This chemical is therefore indispensable for R&D laboratories and fine chemical manufacturers serving the pharmaceutical and biotechnology industries.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) around piperazine-containing compounds.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a versatile linker component in the design of heterobifunctional molecules for targeted protein degradation.
• Peptidomimetic Synthesis: Employed in the creation of peptide analogs and mimetics where the Boc-protected piperazine enhances metabolic stability and bioavailability.
• Library Synthesis for High-Throughput Screening (HTS): A valuable reagent for generating diverse compound libraries to identify new biological probes and drug leads.
• Chemical Biology Tool Development: Incorporated into molecular probes for studying enzyme function, receptor binding, and cellular signaling pathways.

Basic Information

Product Name	2-(4-n-Boc-Piperazin-1-Yl)Methylbenzoic Acid
CAS No.	914349-53-4
Molecular Formula	C18H26N2O4
Molecular Weight	334.41 g/mol
Synonyms	2-[(4-{[(tert-Butoxy)carbonyl]amino}piperazin-1-yl)methyl]benzoic Acid; 2-[(4-Boc-piperazin-1-yl)methyl]benzoic Acid; 2-((4-(tert-Butoxycarbonyl)piperazin-1-yl)methyl)benzoic Acid; 2-[(4-Boc-1-piperazinyl)methyl]benzoic Acid; 2-(4-Boc-piperazin-1-ylmethyl)benzoic Acid; Benzoic acid, 2-[(4-[[(1,1-dimethylethoxy)carbonyl]amino]-1-piperazinyl)methyl]-; 914349-53-4
EINECS	Contact for details

Quality Control

Our 2-(4-n-Boc-Piperazin-1-Yl)Methylbenzoic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment. We support compliance with relevant guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.