Description

trans-1-Cbz-3-Fluoro-4-Hydroxypiperidine is a high-purity, fluorinated piperidine derivative that serves as a critical chiral building block in modern organic synthesis. Its unique structure, featuring orthogonal protecting groups and a fluorine atom, makes it an invaluable intermediate for constructing complex bioactive molecules with enhanced metabolic stability and binding affinity. This compound is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of new therapeutic agents, particularly in medicinal chemistry programs targeting CNS disorders and oncology.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially in protease inhibitor and receptor modulator research.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies to introduce fluorine atoms, which can improve a compound's pharmacokinetic profile, membrane permeability, and metabolic stability.
• API Development: Serves as a precursor in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs) for preclinical and clinical development.
• Chemical Biology Probes: Employed in the creation of labeled compounds and molecular probes for studying biological pathways and enzyme functions.
• Asymmetric Synthesis: Utilized as a scaffold or chiral auxiliary in stereoselective reactions to construct complex, enantiomerically pure molecules.
• Contract Research & Manufacturing (CRO/CMO): Supplied to outsourcing partners who require reliable, high-quality building blocks for client projects.

Basic Information

Product Name	trans-1-Cbz-3-Fluoro-4-Hydroxypiperidine
CAS No.	913574-96-6
Molecular Formula	C13H16FNO3
Molecular Weight	253.27 g/mol
Synonyms	trans-1-[(Benzyloxy)carbonyl]-3-fluoro-4-hydroxypiperidine; (3R,4R)-1-[(Benzyloxy)carbonyl]-3-fluoro-4-hydroxypiperidine; (3S,4S)-1-[(Benzyloxy)carbonyl]-3-fluoro-4-hydroxypiperidine; 1-Cbz-3-fluoro-4-hydroxypiperidine (trans); trans-1-Carbobenzoxy-3-fluoro-4-hydroxypiperidine; trans-3-Fluoro-4-hydroxy-1-N-Cbz-piperidine; trans-N-Cbz-3-fluoro-4-hydroxypiperidine; 913574-96-6
EINECS	Contact for details

Quality Control

Our trans-1-Cbz-3-Fluoro-4-Hydroxypiperidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines to support our clients' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.