Description

5-Bromo-2-Chloropyrazine is a high-purity halogenated pyrazine derivative serving as a critical building block in advanced organic synthesis. Its unique bifunctional halogen substitution pattern makes it a versatile and valuable intermediate for constructing complex heterocyclic systems. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and material science industries, where it is used to develop new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the pyrazine core for bioactivity.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or conductive polymers.
• Chemical Biology: Employed as a molecular probe or a tagging reagent due to its reactive halogen sites for bioconjugation.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions to introduce the pyrazine moiety into more complex structures.
• Ligand Synthesis: Used in the preparation of specialized ligands for catalysis and coordination chemistry.

Basic Information

Product Name	5-Bromo-2-Chloropyrazine
CAS No.	912773-21-8
Molecular Formula	C4H2BrClN2
Molecular Weight	193.43 g/mol
Synonyms	2-Chloro-5-bromopyrazine; 5-Bromo-2-chloro-1,4-diazine; 2-Chloro-5-bromo-1,4-diazine; 5-Bromo-2-chloropyrazine; Bromochloropyrazine; Pyrazine, 5-bromo-2-chloro-; 912773-21-8 (CAS)
EINECS	Contact for details

Quality Control

Every batch of 5-Bromo-2-Chloropyrazine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.