Description

3-Phenyl-1-(Toluene-4-Sulfonyl)-Piperazine is a high-purity, advanced pharmaceutical intermediate characterized by its piperazine core functionalized with phenyl and tosyl protecting groups. This compound matters for its critical role in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research and development. Pharmaceutical companies and contract research organizations (CROs) need it as a key building block for creating novel drug candidates targeting central nervous system (CNS) disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of novel drug candidates, particularly in medicinal chemistry.
• API Synthesis: Used in the research and development of Active Pharmaceutical Ingredients (APIs), especially for neurological and psychiatric applications.
• Chemical Research: Serves as a versatile scaffold in academic and industrial R&D for exploring new chemical entities and structure-activity relationships (SAR).
• Process Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Custom Synthesis: A starting material for the contract manufacturing of specialized, high-value fine chemicals and reference standards.

Basic Information

Product Name	3-Phenyl-1-(Toluene-4-Sulfonyl)-Piperazine
CAS No.	912763-26-9
Molecular Formula	C17H20N2O2S
Molecular Weight	316.42 g/mol
Synonyms	1-Tosyl-3-phenylpiperazine; 3-Phenyl-1-(p-tolylsulfonyl)piperazine; 3-Phenyl-1-(4-toluenesulfonyl)piperazine; 1-(4-Methylphenyl)sulfonyl-3-phenylpiperazine; N-(p-Toluenesulfonyl)-3-phenylpiperazine; 3-Phenyl-1-tosylpiperazine; 912763-26-9; 3-Phenyl-1-(toluene-4-sulfonyl)piperazine
EINECS	Contact for details

Quality Control

Our 3-Phenyl-1-(Toluene-4-Sulfonyl)-Piperazine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical-grade intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The product is moisture-sensitive (hygroscopic); ensure the container is sealed after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.