Description

4-[(1S)-(4-Dimethylamino)-1-(4-Fluotophenyl)-1-Hydroxybutyl]-3-(Hydroxymethyl)Benzonitrile (2R,3R)-2,3-Bis[(4-Methylbenzoyl)Oxy]Butanedioic Acid is a high-purity, complex chiral intermediate of significant importance in advanced pharmaceutical synthesis. This compound matters because it provides a critical, stereochemically defined building block for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring high specificity. It is primarily needed by R&D laboratories and production facilities in the pharmaceutical and fine chemical industries engaged in the synthesis of sophisticated drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the multi-step synthesis of novel drug candidates, particularly for central nervous system (CNS) and metabolic disorder targets.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs).
• Process Chemistry: Serves as a critical starting material or intermediate in scaling up API manufacturing processes under GMP conditions.
• Asymmetric Synthesis: Utilized in reactions that require high enantiomeric purity to construct complex molecular architectures.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in API production.
• Custom Synthesis: Acts as a foundational compound for the custom synthesis of proprietary derivatives and analogs for specialized research programs.

Basic Information

Item	Detail
Product Name	4-[(1S)-(4-Dimethylamino)-1-(4-Fluotophenyl)-1-Hydroxybutyl]-3-(Hydroxymethyl)Benzonitrile (2R,3R)-2,3-Bis[(4-Methylbenzoyl)Oxy]Butanedioic Acid
CAS No.	912452-31-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Rosuvastatin Intermediate; (2R,3R)-Di-p-toluoyl-D-tartaric acid salt of Rosuvastatin key chiral amine; (3R,5S)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-(N-methylmethanesulfonamido)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid intermediate; (2R,3R)-2,3-Bis(4-methylbenzoyloxy)succinic acid compound; Chiral Rosuvastatin precursor; 4-(4-Fluorophenyl)-2-[(1S)-1-[(3S,5R)-6-oxo-3,5-dihydroxyhex-1-en-1-yl]-2-(4-methylphenylsulfonamido)ethyl]-6-isopropylpyrimidine-5-carbonitrile derivative; Advanced statin intermediate; API Intermediate 912452-31-4
EINECS	Contact for details

Quality Control

Our 4-[(1S)-(4-Dimethylamino)-1-(4-Fluotophenyl)-1-Hydroxybutyl]-3-(Hydroxymethyl)Benzonitrile (2R,3R)-2,3-Bis[(4-Methylbenzoyl)Oxy]Butanedioic Acid is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including chiral HPLC, to ensure high enantiomeric purity and chemical identity. Certificates of Analysis (COA) detailing purity, impurities, and chiral excess are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.