Description

Nicotine n-D-Glucoside is a glycosylated derivative of nicotine, representing a significant metabolite and a compound of interest in advanced biochemical research. This specific conjugate is crucial for studying nicotine metabolism, detoxification pathways, and the development of novel analytical standards. It serves as a vital reference material and intermediate for researchers and manufacturers in the pharmaceutical, life science, and agrochemical sectors who require high-purity, well-characterized compounds for method development and product innovation.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and identification of nicotine metabolites in pharmacokinetic and toxicological studies.
• Biochemical Research: A key substrate for investigating Phase II metabolism (glucuronidation) of alkaloids, enzyme kinetics, and detoxification mechanisms.
• Analytical Chemistry: Serves as a critical standard for developing and validating LC-MS/MS, HPLC, and other chromatographic methods in forensic and clinical laboratories.
• Agrochemical Studies: Employed in research on nicotine's environmental fate, plant-insect interactions, and the development of novel, targeted bioactive compounds.
• Metabolite Synthesis: Acts as a sophisticated intermediate for the chemical or enzymatic synthesis of other nicotine-derived metabolites and conjugates.

Basic Information

Product Name	Nicotine n-D-Glucoside
CAS No.	911474-72-1
Molecular Formula	C16H22N2O6
Molecular Weight	338.36 g/mol
Synonyms	Nicotine Glucuronide; Nicotine N-Glucuronide; Nicotine β-D-Glucuronide; (S)-Nicotine N-β-D-Glucuronide; 1-((2S)-1-Methyl-2-(3-pyridinyl)pyrrolidin-2-yl)-β-D-glucopyranuronic acid; Nicotine metabolite N-glucuronide; Cotinine precursor glucuronide
EINECS	Contact for details

Quality Control

Every batch of Nicotine n-D-Glucoside is manufactured and analyzed under strict quality management protocols to ensure identity, purity, and consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed results for parameters including assay, related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.