Description

2-(2,2,2-Trifluoro-Ethyl)-Piperazine is a high-purity, fluorinated piperazine derivative, a key building block in advanced organic synthesis. This compound is valued for its ability to introduce a trifluoroethyl-piperazine moiety, which can significantly alter the physicochemical and metabolic properties of target molecules. It is primarily utilized by research and development chemists and process scale-up teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical synthon for the development of new drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides where the fluorine atoms enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for nitrogen-containing ligands used in asymmetric catalysis and metal complexation.
• Material Science Research: Incorporated into polymers and specialty chemicals to modify surface properties and thermal stability.
• Custom Synthesis and Contract Manufacturing: Supplied to CROs and CDMOs for client-specific projects requiring fluorinated heterocycles.

Basic Information

Product Name	2-(2,2,2-Trifluoro-Ethyl)-Piperazine
CAS No.	910444-24-5
Molecular Formula	C6H11F3N2
Molecular Weight	168.16 g/mol
Synonyms	1-(2,2,2-Trifluoroethyl)piperazine; 2-(2,2,2-Trifluoroethyl)piperazine; 2,2,2-Trifluoroethyl-piperazine; N-(2,2,2-Trifluoroethyl)piperazine; Piperazine, 2-(2,2,2-trifluoroethyl)-; 910444-24-5; 2-(2,2,2-Trifluoroethyl)-1,4-diazacyclohexane
EINECS	Contact for details

Quality Control

Our 2-(2,2,2-Trifluoro-Ethyl)-Piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.