Description

tert-Butyl 4-(3-(Hydroxymethyl)Phenyl)Piperidine-1-Carboxylate is a high-purity, protected piperidine derivative that serves as a critical building block in advanced organic synthesis. Its molecular architecture, featuring both a hydroxymethylphenyl group and a Boc-protected amine, makes it an invaluable intermediate for constructing complex pharmacologically active molecules. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel therapeutic agents, particularly in central nervous system (CNS) and oncology drug candidates.
• Organic Synthesis Building Block: Used in multi-step synthesis for constructing complex molecular scaffolds, leveraging its reactive hydroxymethyl and protected amine functionalities.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization processes to develop new chemical entities.
• Peptidomimetic Synthesis: Serves as a constrained amino acid surrogate or a rigid spacer in the design of peptide mimics and bioactive compounds.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying biological pathways and target identification.
• Custom Synthesis & Contract Manufacturing: A starting material for custom synthesis projects and scale-up manufacturing under GMP or non-GMP conditions.

Basic Information

Product Name	tert-Butyl 4-(3-(Hydroxymethyl)Phenyl)Piperidine-1-Carboxylate
CAS No.	909422-39-5
Molecular Formula	C17H25NO3
Molecular Weight	291.39 g/mol
Synonyms	1-Boc-4-(3-Hydroxymethylphenyl)piperidine; 1-(tert-Butoxycarbonyl)-4-(3-(hydroxymethyl)phenyl)piperidine; 4-(3-Hydroxymethylphenyl)piperidine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-[3-(hydroxymethyl)phenyl]piperidine-1-carboxylate; 909422-39-5; 1-Piperidinecarboxylic acid, 4-[3-(hydroxymethyl)phenyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(3-(Hydroxymethyl)Phenyl)Piperidine-1-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support development and commercial projects with material suitable for research use and can provide grades aligned with ICH guidelines for impurity identification and control.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.