Description

1-(3,4-Difluoro-Phenyl)-Piperazin-2-One is a high-purity pharmaceutical intermediate and research chemical characterized by its piperazinone core and difluorophenyl substituent. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is primarily utilized by pharmaceutical R&D laboratories, custom synthesis providers, and advanced material scientists seeking to develop new therapeutic agents and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, especially in CNS-targeted therapies and oncology.
• Organic Synthesis Building Block: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Research & Development: Serves as a standard or reagent in academic and industrial research exploring piperazine and fluorinated compound chemistry.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs producing specialized compounds for client projects.
• Chemical Reference Standard: Employed for analytical method development, validation, and quality control in API manufacturing.

Basic Information

Product Name	1-(3,4-Difluoro-Phenyl)-Piperazin-2-One
CAS No.	907972-67-2
Molecular Formula	C10H10F2N2O
Molecular Weight	212.20 g/mol
Synonyms	1-(3,4-Difluorophenyl)piperazin-2-one; 3,4-Difluoro-N-(2-oxopiperazin-1-yl)aniline; 1-(3,4-Difluorophenyl)-2-piperazinone; 2-Piperazinone, 1-(3,4-difluorophenyl)-; 907972-67-2; CAS 907972-67-2
EINECS	Contact for details

Quality Control

Our 1-(3,4-Difluoro-Phenyl)-Piperazin-2-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong acids, strong bases, and oxidizing agents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.