Description

2-Piperazinone, 1-Cyclobutyl- is a specialized heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel pharmacologically active molecules, particularly within medicinal chemistry. Pharmaceutical R&D and fine chemical synthesis laboratories need this high-purity intermediate to construct complex molecular architectures for drug discovery programs targeting various therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Ligand and Catalyst Development: Employed in the design and synthesis of novel ligands for asymmetric catalysis and organometallic complexes.
• Agrochemical Synthesis: Functions as a building block for developing new generation herbicides and fungicides with improved efficacy.
• Peptidomimetic Chemistry: Utilized to introduce constrained piperazinone motifs into peptide analogs to enhance metabolic stability and bioavailability.
• Material Science Research: Investigated as a monomer or cross-linking agent for the development of specialty polymers with unique thermal or mechanical properties.

Basic Information

Product Name	2-Piperazinone, 1-Cyclobutyl-
CAS No.	907972-26-3
Molecular Formula	C8H14N2O
Molecular Weight	154.21 g/mol
Synonyms	1-Cyclobutylpiperazin-2-one; 1-Cyclobutyl-2-piperazinone; 1-Cyclobutylpiperazinone; Cyclobutylpiperazinone; N-Cyclobutyl-2-piperazinone; 2-Oxo-1-cyclobutylpiperazine; 1-Cyclobutyl-1,4-diazepan-2-one (related structure); 907972-26-3 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our 2-Piperazinone, 1-Cyclobutyl- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.