Description

(2S,5R)-2-Ethyl-5-Methyl-n-Boc-Piperazine is a high-purity, stereochemically defined chiral piperazine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in providing a protected, enantiomerically pure scaffold essential for constructing complex molecules with precise three-dimensional architecture. This compound is primarily needed by pharmaceutical and biotechnology R&D teams for the development of new active pharmaceutical ingredients (APIs), particularly in creating peptidomimetics and other sophisticated therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, especially for central nervous system (CNS) and antiviral targets.
• Peptidomimetic Scaffold: Used to construct constrained peptide analogs and protease inhibitors by providing a rigid, substituted piperazine core.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for developing chiral ligands and organocatalysts.
• Chemical Biology Probe Development: Employed in creating tagged molecular probes for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high stereochemical fidelity.
• Academic & Industrial Research: Utilized in research laboratories for methodological studies in stereoselective synthesis and medicinal chemistry.

Basic Information

Product Name	(2S,5R)-2-Ethyl-5-Methyl-n-Boc-Piperazine
CAS No.	906559-60-2
Molecular Formula	C12H24N2O2
Molecular Weight	228.33 g/mol
Synonyms	1-Boc-2-ethyl-5-methylpiperazine (2S,5R)-; tert-Butyl (2S,5R)-2-ethyl-5-methylpiperazine-1-carboxylate; (2S,5R)-1-(tert-Butoxycarbonyl)-2-ethyl-5-methylpiperazine; (2S,5R)-2-Ethyl-5-methyl-1-(tert-butoxycarbonyl)piperazine; BOC-(2S,5R)-2-Ethyl-5-methylpiperazine; N-Boc-(2S,5R)-2-ethyl-5-methylpiperazine; (2S,5R)-2-Ethyl-5-methylpiperazine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for advanced pharmaceutical intermediates. Each batch is characterized using chiral HPLC, NMR, and mass spectrometry to confirm identity, stereochemical purity, and chemical purity. Certificates of Analysis (COA) are available upon request, detailing all critical parameters. We adhere to cGMP principles where applicable to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture uptake, which can affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% de
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.