Description

tert-Butyl 4-Cyano-4-p-Tolylpiperidine-1-Carboxylate is a high-value, multi-functional piperidine derivative serving as a critical building block in advanced organic synthesis. This compound matters because it provides a protected amine and a versatile nitrile group, enabling efficient construction of complex molecular architectures for pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical industry for the synthesis of active pharmaceutical ingredients (APIs) and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon for the development of central nervous system (CNS) active drugs, kinase inhibitors, and other therapeutic small molecules.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and plant growth regulators leveraging its piperidine scaffold.
• Chemical Biology & Proteomics: Serves as a versatile linker or spacer molecule in the design of chemical probes and bioconjugates.
• Material Science Precursor: Potential monomer or precursor for specialty polymers and advanced organic materials.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological development and novel reaction exploration.

Basic Information

Product Name	tert-Butyl 4-Cyano-4-p-Tolylpiperidine-1-Carboxylate
CAS No.	906369-93-5
Molecular Formula	C18H24N2O2
Molecular Weight	300.40 g/mol
Synonyms	1-Boc-4-cyano-4-(p-tolyl)piperidine; 4-Cyano-4-(4-methylphenyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl 4-cyano-4-(4-methylphenyl)piperidine-1-carboxylate; 4-(4-Methylphenyl)-4-cyano-1-piperidinecarboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-cyano-4-(p-tolyl)piperidine; Boc-4-cyano-4-p-tolylpiperidine; 906369-93-5
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Cyano-4-p-Tolylpiperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply and traceability for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary for long-term storage. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.