Description

α-Amine-ω-Propionic Acid Hexaethylene Glycol is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a primary amine group at one terminus and a carboxylic acid group at the other. This unique bifunctionality is critical for creating stable, water-soluble conjugates and crosslinks between diverse molecules and surfaces. It is an essential building block for researchers and manufacturers in the life sciences and advanced materials sectors who require precise, reproducible, and biocompatible linkers. The compound is particularly valuable for bioconjugation, surface modification, and the synthesis of functional hydrogels and drug delivery systems.

Application

• Bioconjugation and Protein PEGylation: Used to create stable amide bonds for attaching peptides, proteins, or antibodies to other biomolecules, nanoparticles, or solid supports, improving solubility and stability.
• Drug Delivery System Synthesis: Serves as a key linker in constructing prodrugs, polymer-drug conjugates, and micellar or nanoparticle-based carriers for controlled release.
• Surface Functionalization: Enables the covalent attachment of bioactive ligands to materials (e.g., gold, silica, polymers) for biosensor development, diagnostic assays, and cell culture substrates.
• Hydrogel and Biomaterial Fabrication: Acts as a crosslinking agent to form biocompatible and tunable hydrogel networks for tissue engineering and 3D cell culture applications.
• Diagnostic Reagent Preparation: Utilized to conjugate enzymes, fluorescent dyes, or haptens to antibodies or other proteins in immunoassay and diagnostic kit development.
• Affinity Chromatography Ligand Coupling: Facilitates the immobilization of specific ligands onto chromatography resins for protein purification.

Basic Information

Product Name	α-Amine-ω-Propionic Acid Hexaethylene Glycol
CAS No.	905954-28-1
Molecular Formula	C21H43NO11
Molecular Weight	485.57 g/mol
Synonyms	6-Amino-3,6,9,12,15,18-hexaoxahenicosanoic acid; α-Amino-ω-propionic acid-hexaethylene glycol; H2N-PEG6-COOH; Amine-PEG6-Acid; NH2-PEG6-CH2CH2COOH; 8-Aza-3,6,9,12,15,18-hexaoxahenicosanoic acid; Amino-PEG6-propionic acid; Heterobifunctional PEG, Amine and Carboxyl
EINECS	Contact for details

Quality Control

Our α-Amine-ω-Propionic Acid Hexaethylene Glycol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and assay, NMR for structural confirmation, and mass spectrometry to ensure identity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP guidelines where applicable, ensuring material suitable for research and commercial development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere, consider sealing under argon or nitrogen. Keep the container tightly sealed when not in use to prevent absorption of moisture and carbon dioxide.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 90.0% (by titration)
Water Content (KF)	≤ 1.0%
Molecular Weight Confirmation (MS)	Conforms (M+Na+ ~508)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.