Description

(S)-3-(Piperazin-1-Yl)Propane-1,2-Diol is a chiral piperazine derivative that serves as a critical building block in modern pharmaceutical synthesis. This compound matters because its unique structure, featuring both a piperazine ring and a diol moiety, makes it a versatile intermediate for constructing complex molecules with high biological activity. Pharmaceutical R&D and fine chemical manufacturers need it for the development of targeted therapeutics, particularly in areas like central nervous system (CNS) agents and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of active pharmaceutical ingredients (APIs), especially for neurological and psychiatric drugs.
• Ligand Synthesis: Used in the preparation of complex ligands for catalysis and medicinal chemistry applications.
• Bioconjugation Chemistry: The diol and amine functional groups enable its use as a linker or spacer in bioconjugate and prodrug development.
• Chemical Biology Probes: Serves as a core structure for designing molecular probes to study biological pathways and protein interactions.
• Asymmetric Synthesis: Employed as a chiral auxiliary or precursor in stereoselective synthesis to introduce specific three-dimensional configurations.
• Polymer Modification: Can be utilized to introduce functional amine and hydroxyl groups into polymer backbones for specialty materials.

Basic Information

Item	Details
Product Name	(S)-3-(Piperazin-1-Yl)Propane-1,2-Diol
CAS No.	904896-44-2
Molecular Formula	C7H16N2O2
Molecular Weight	160.22 g/mol
Synonyms	(S)-3-(1-Piperazinyl)-1,2-propanediol; (S)-1-(2,3-Dihydroxypropyl)piperazine; (S)-3-Piperazin-1-yl-propane-1,2-diol; (S)-1-Piperazinepropanediol; (S)-3-Piperazinyl-1,2-propanediol; (S)-1,2-Propanediol, 3-(1-piperazinyl)-; (S)-PG-PZ
EINECS	Contact for details

Quality Control

Our (S)-3-(Piperazin-1-Yl)Propane-1,2-Diol is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding R&D and scale-up processes. We provide comprehensive Certificates of Analysis (COA) for each batch, detailing purity, chiral purity, and impurity profiles. While typically supplied as a high-purity research chemical, production can be aligned with cGMP guidelines for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.