Description

4-(3-Carboxy-Pyridin-2-Yl)-2-Methyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-value, protected piperazine-pyridine carboxylic acid derivative that serves as a critical building block in modern organic synthesis. This compound matters because it provides a versatile chiral scaffold with orthogonal protecting groups, enabling the precise construction of complex molecules for pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the areas of central nervous system (CNS) and antiviral therapeutics.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of novel drug candidates targeting neurological disorders.
• API Synthesis: Used in the multi-step synthesis of complex molecules, leveraging its tert-butyl ester and piperazine moieties for selective deprotection and functionalization.
• Medicinal Chemistry Research: A valuable scaffold for structure-activity relationship (SAR) studies and library synthesis in early-stage drug discovery.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of target compounds under Good Manufacturing Practice (GMP) guidelines.
• Ligand and Catalyst Development: Potential precursor for creating novel chiral ligands used in asymmetric catalysis.
• Chemical Biology Probes: Can be utilized to create tagged molecules for studying biological pathways and target engagement.

Basic Information

Product Name	4-(3-Carboxy-Pyridin-2-Yl)-2-Methyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	904817-78-3
Molecular Formula	C17H23N3O4
Molecular Weight	333.38 g/mol
Synonyms	2-Methyl-4-(3-pyridinecarboxyl-2-yl)piperazine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-(3-carboxypyridin-2-yl)-2-methylpiperazine-1-carboxylate; 2-Methyl-4-(3-carboxy-2-pyridyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; 1-Boc-2-methyl-4-(3-carboxy-2-pyridyl)piperazine; 904817-78-3; (2-Methyl-4-(3-carboxy-2-pyridyl)piperazin-1-yl)-tert-butylcarboxylate
EINECS	Contact for details

Quality Control

Our 4-(3-Carboxy-Pyridin-2-Yl)-2-Methyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality control protocols to ensure high chemical purity and batch-to-batch consistency suitable for research and development. Products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each batch to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 98.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.