Description

2-Methyl-5-Phenyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester CAS NO 904816-67-7 is a high-purity, protected piperazine derivative serving as a critical building block in advanced organic synthesis. This compound is essential for medicinal chemistry research and development, enabling the construction of complex molecular architectures with high precision. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers for the synthesis of novel active pharmaceutical ingredients (APIs) and other biologically relevant compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, particularly in central nervous system (CNS) and oncology therapeutic areas.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing diverse compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Peptidomimetic Synthesis: Facilitates the creation of peptide analogs and mimetics due to its piperazine core, which can mimic peptide bonds and influence pharmacokinetic properties.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Custom Synthesis & Contract Manufacturing: Serves as a starting material for custom synthesis projects undertaken by CDMOs (Contract Development and Manufacturing Organizations).

Basic Information

Product Name	2-Methyl-5-Phenyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	904816-67-7
Molecular Formula	C16H24N2O2
Molecular Weight	276.38 g/mol
Synonyms	tert-Butyl 2-methyl-5-phenylpiperazine-1-carboxylate; 1-Boc-2-methyl-5-phenylpiperazine; (R/S)-tert-Butyl 2-methyl-5-phenylpiperazine-1-carboxylate; 2-Methyl-5-phenyl-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; 1,1-Dimethylethyl 2-methyl-5-phenyl-1-piperazinecarboxylate; 2-Methyl-5-phenylpiperazine-1-carboxylic acid tert-butyl ester; N-Boc-2-methyl-5-phenylpiperazine
EINECS	Contact for details

Quality Control

Our 2-Methyl-5-Phenyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the stringent requirements for pharmaceutical R&D applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and conformance to agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (for specific enantiomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.