Description

4-[2-Hydroxy-2-(4-Methoxy-Phenyl)-Ethyl]-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its piperazine core and protected carboxylic acid functionality. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), offering a versatile building block for medicinal chemistry research and process development. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers engaged in the production of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those targeting neurological and cardiovascular disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its modifiable piperazine and ester groups.
• API Process Development: Serves as a critical precursor in scaling up synthetic routes for new chemical entities (NCEs).
• Custom Synthesis: Employed by contract research and manufacturing organizations (CRAMOs) for client-specific molecule assembly.
• Bioconjugation & Prodrug Development: The tert-butyl ester and hydroxyl groups provide handles for further chemical modification and linker attachment.

Basic Information

Product Name	4-[2-Hydroxy-2-(4-Methoxy-Phenyl)-Ethyl]-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	904815-65-2
Molecular Formula	C18H28N2O4
Molecular Weight	336.43 g/mol
Synonyms	1-Boc-4-[2-hydroxy-2-(4-methoxyphenyl)ethyl]piperazine; tert-Butyl 4-[2-hydroxy-2-(4-methoxyphenyl)ethyl]piperazine-1-carboxylate; 4-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)piperazine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-[2-hydroxy-2-(4-methoxyphenyl)ethyl]piperazine; Boc-4-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)piperazine; 904815-65-2
EINECS	Contact for details

Quality Control

Our 4-[2-Hydroxy-2-(4-Methoxy-Phenyl)-Ethyl]-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your internal specifications and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.