Description

Tofogliflozin CAS NO 903565-83-3 is a potent, selective, and orally active inhibitor of sodium-glucose cotransporter 2 (SGLT2). This compound is of significant interest in the pharmaceutical industry for its role in the management of type 2 diabetes mellitus. It is primarily required by pharmaceutical research and development organizations, active pharmaceutical ingredient (API) manufacturers, and contract research organizations (CROs) engaged in metabolic disease therapeutics.

Application

• Active Pharmaceutical Ingredient (API): Serves as the core active component in the formulation of SGLT2 inhibitor class anti-diabetic medications.
• Pharmaceutical R&D: Used as a reference standard and building block in preclinical and clinical research for developing new diabetes treatments.
• Metabolic Disease Studies: Employed in biochemical and pharmacological research to investigate SGLT2 mechanisms and glucose homeostasis.
• Formulation Development: Utilized in the development of various dosage forms, including tablets and capsules.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the commercial-scale production of finished drug products.
• Bioequivalence & Generic Drug Development: Acts as a critical standard in the development and regulatory filing of generic versions of SGLT2 inhibitor drugs.

Basic Information

Product Name	Tofogliflozin
CAS No.	903565-83-3
Molecular Formula	C₂₂H₂₁FO₆S
Molecular Weight	432.46 g/mol
Synonyms	(1S,2S,3S,4R,5S)-5-[4-ethylbenzyl]-2,3,4-trihydroxy-1-(4-methylphenyl)pentyl 6-O-ethoxy-β-D-glucopyranoside; CSG452; Tofogliflozin hydrate; Apleway; Deberza; 1-(β-D-Glucopyranosyl)-4-methyl-3-[5-(4-ethylphenyl)-2-thienylmethyl]benzene
EINECS	Contact for details

Quality Control

Our Tofogliflozin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC purity assay, identification by IR and NMR, and stringent control of related substances and residual solvents to ensure compliance with ICH guidelines. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming the product meets the agreed specifications for pharmaceutical R&D and API synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time conforms to reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.5%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.