Description

2-Methyl-2-p-Tolyl-Morpholine-4-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound is valued for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and analgesic research. It is primarily sought by pharmaceutical R&D laboratories, process development chemists, and manufacturers specializing in novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of proprietary drug candidates, especially those targeting neurological pathways.
• API Synthesis: Serves as a key chiral building block for constructing complex molecular architectures in final Active Pharmaceutical Ingredient (API) manufacturing.
• Medicinal Chemistry Research: Used in discovery and optimization phases for developing new chemical entities with potential analgesic or CNS activity.
• Process Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial production scales.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development, quality control, and regulatory submissions.
• Custom Synthesis: A starting point for the custom synthesis of specialized derivatives and analogs for biological screening.

Basic Information

Product Name	2-Methyl-2-p-Tolyl-Morpholine-4-Carboxylic Acid tert-Butyl Ester
CAS No.	902836-80-0
Molecular Formula	C17H25NO3
Molecular Weight	291.39 g/mol
Synonyms	tert-Butyl 2-methyl-2-(4-methylphenyl)morpholine-4-carboxylate; 2-Methyl-2-(p-tolyl)morpholine-4-carboxylic acid tert-butyl ester; 4-(tert-Butoxycarbonyl)-2-methyl-2-(4-methylphenyl)morpholine; 2-p-Tolyl-2-methylmorpholine-4-carboxylic acid tert-butyl ester; BOC-Protected 2-Methyl-2-p-tolylmorpholine
EINECS	Contact for details

Quality Control

Our 2-Methyl-2-p-Tolyl-Morpholine-4-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, supporting your regulatory and quality assurance requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.