Description

1-(2-Trifluoromethyl-Benzyl)-Piperidine-4-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique piperidine carboxylic acid core and trifluoromethyl benzyl substituent. This compound is of significant commercial importance for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral research. It is primarily needed by pharmaceutical R&D laboratories, contract research and manufacturing organizations (CROs/CMOs), and fine chemical suppliers serving the global life sciences sector.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, especially for neurological and psychiatric disorders.
• API Synthesis: Serves as a crucial precursor in multi-step synthetic routes for complex target molecules in medicinal chemistry.
• Chemical Biology Research: Used as a scaffold or probe in the study of biological targets and mechanisms of action.
• Process Development: Employed in the scale-up and optimization of synthetic pathways for clinical trial material and commercial API production.
• Reference Standard: Utilized as an analytical standard for quality control and method validation in pharmaceutical manufacturing.
• Custom Synthesis: A starting point for the preparation of specialized derivatives and analogs for proprietary research programs.

Basic Information

Product Name	1-(2-Trifluoromethyl-Benzyl)-Piperidine-4-Carboxylic Acid
CAS No.	901920-49-8
Molecular Formula	C15H16F3NO2
Molecular Weight	299.29 g/mol
Synonyms	1-[(2-Trifluoromethyl)benzyl]piperidine-4-carboxylic acid; 4-Piperidinecarboxylic acid, 1-[(2-(trifluoromethyl)phenyl)methyl]-; 1-(2-(Trifluoromethyl)benzyl)piperidine-4-carboxylic acid; 1-(2-Trifluoromethylbenzyl)piperidine-4-carboxylic acid; 1-(2-Trifluoromethyl-benzyl)-piperidine-4-carboxylic acid; 1-(2-Trifluoromethylbenzyl)-4-piperidinecarboxylic acid; 1-(2-Trifluoromethylbenzyl)isonipecotic acid; 1-(2-Trifluoromethylbenzyl)-4-carboxypiperidine
EINECS	Contact for details

Quality Control

Our 1-(2-Trifluoromethyl-Benzyl)-Piperidine-4-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring the material is suitable for demanding pharmaceutical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.