Description

4-(2-Hydroxy-1-Methyl-Ethyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-value, protected piperazine derivative that serves as a critical building block in advanced organic synthesis. Its structure, featuring both a tert-butyloxycarbonyl (Boc) protecting group and a hydroxymethyl side chain, makes it an essential intermediate for constructing complex molecules with precise stereochemistry and functionality. This compound is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral therapies.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of complex drug candidates, especially those containing piperazine or morpholine scaffolds.
• API Development: Used in research and process chemistry for constructing the core structure of potential new medicines targeting neurological disorders.
• Peptidomimetics & PROTACs: Serves as a versatile linker or spacer unit in the design of peptide mimics and Proteolysis Targeting Chimeras (PROTACs) for targeted protein degradation.
• Chemical Biology Probes: Employed to create tagged or functionalized molecules for studying biological pathways and protein interactions.
• Asymmetric Synthesis: The chiral center allows its use in stereoselective reactions to produce enantiomerically pure compounds.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Item	Details
Product Name	4-(2-Hydroxy-1-Methyl-Ethyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	900535-75-3
Molecular Formula	C12H24N2O3
Molecular Weight	244.33 g/mol
Synonyms	1-Boc-4-(2-hydroxy-1-methylethyl)piperazine; tert-Butyl 4-(2-hydroxy-1-methylethyl)piperazine-1-carboxylate; 4-(1-Hydroxypropan-2-yl)piperazine-1-carboxylic acid tert-butyl ester; N-Boc-4-(2-hydroxypropyl)piperazine; (2-Hydroxy-1-methylethyl)piperazine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-(2-hydroxy-1-methylethyl)piperazine
EINECS	Contact for details

Quality Control

Our 4-(2-Hydroxy-1-Methyl-Ethyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.