Description

1-(5-Chloro-2-Methoxyphenyl)Piperazine Hydrochloride is a high-purity, versatile pharmaceutical intermediate and research chemical. This compound is critical for the synthesis of complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) targeting the central nervous system. It is primarily sought by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers for its role as a key building block in medicinal chemistry.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel psychoactive substances, antipsychotics, and other CNS-targeting drug candidates.
• Medicinal Chemistry Research: Used as a core scaffold or building block for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Chemical Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical analysis.
• Biochemical Research: Employed in studies investigating receptor-ligand interactions, particularly those involving serotonin and dopamine receptor subtypes.
• Process Chemistry Development: Used in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.

Basic Information

Product Name	1-(5-Chloro-2-Methoxyphenyl)Piperazine Hydrochloride
CAS No.	99857-72-4
Molecular Formula	C11H15ClN2O • HCl
Molecular Weight	263.16 g/mol
Synonyms	5-Chloro-2-methoxyphenylpiperazine hydrochloride; 1-(5-Chloro-2-methoxyphenyl)piperazine HCl; 5-Cl-2-MeO-PP HCl; 5-Chloro-2-methoxy-1-piperazinobenzene hydrochloride; 2-Methoxy-5-chlorophenylpiperazine hydrochloride; 99857-72-4; 5-Chloro-2-methoxyphenylpiperazine monohydrochloride
EINECS	Contact for details

Quality Control

Our 1-(5-Chloro-2-Methoxyphenyl)Piperazine Hydrochloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing including HPLC, NMR, and FTIR to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and relevant industry standards for research and pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.