Description

(+/-)-11-Hydroxy-5Z,8Z,12E,14Z,17Z-Eicosapentaenoic Acid CAS NO 99217-78-4 is a hydroxylated derivative of eicosapentaenoic acid (EPA), a key ω-3 fatty acid. This specialized metabolite is of significant interest in biochemical research and pharmaceutical development due to its role as a bioactive lipid mediator. It is primarily utilized by researchers and manufacturers in the life sciences, nutraceutical, and pharmaceutical industries for studying inflammation, metabolic pathways, and developing novel therapeutic agents.

Application

• Biochemical Research Standard: Used as a high-purity reference standard for analytical method development and validation in lipidomics and metabolomics studies.
• Pharmaceutical R&D: Serves as a key intermediate or active pharmaceutical ingredient (API) precursor in the development of anti-inflammatory and cardioprotective drugs.
• Cell Signaling Studies: Employed in vitro and in vivo to investigate the mechanisms of oxylipin-mediated signaling pathways and their physiological effects.
• Nutraceutical Development: Explored as a potential bioactive component in advanced dietary supplements targeting metabolic and inflammatory health.
• Enzyme Substrate: Acts as a substrate for studying the activity and specificity of lipoxygenase (LOX) and cytochrome P450 enzymes involved in eicosanoid biosynthesis.

Basic Information

Product Name	(+/-)-11-Hydroxy-5Z,8Z,12E,14Z,17Z-Eicosapentaenoic Acid
CAS No.	99217-78-4
Molecular Formula	C₂₀H₃₀O₃
Molecular Weight	318.45 g/mol
Synonyms	11-Hydroxy-EPA; 11-HEPE; (±)-11-Hydroxy-5Z,8Z,12E,14Z,17Z-eicosapentaenoic acid; 11-Hydroxyeicosapentaenoic acid; 11-HETE (Note: This is a common but potentially misleading abbreviation as it typically refers to arachidonic acid derivatives); 11-Hydroxyicosa-5Z,8Z,12E,14Z,17Z-pentaenoic acid; 11(S)-HETE (for the S-enantiomer); 11(R)-HETE (for the R-enantiomer)
EINECS	Contact for details

Quality Control

Our (+/-)-11-Hydroxy-5Z,8Z,12E,14Z,17Z-Eicosapentaenoic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC and GC-MS, to ensure high purity and identity confirmation. Certificates of Analysis (COA) detailing purity, chromatographic data, and storage recommendations are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95% (Area %)
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Related Substances	≤ 5.0%
Solubility	Soluble in ethanol, DMSO; slightly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.