Description

1,2-Distearoyl-Sn-Glycerol is a high-purity synthetic glyceride, specifically a diglyceride, where two stearic acid chains are esterified to the sn-1 and sn-2 positions of the glycerol backbone. This specific stereochemistry and fatty acid composition make it a critical intermediate and reference standard in advanced lipid research and pharmaceutical development. It is essential for scientists and manufacturers in the life sciences, cosmetics, and specialty chemical sectors who require well-defined lipid molecules for process development, analytical calibration, and formulation studies. Its defined structure ensures reproducibility in applications ranging from lipid nanoparticle (LNP) synthesis to the study of metabolic pathways.

Application

• Lipid Nanoparticle (LNP) Formulation: A key synthetic intermediate and structural component in the development of novel drug delivery systems for mRNA and other nucleic acid therapeutics.
• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification, assay, and impurity profiling of related lipid excipients and active pharmaceutical ingredients (APIs).
• Biochemical Research: Serves as a substrate or intermediate in enzymatic studies of lipid metabolism, including phospholipid and triglyceride biosynthesis pathways.
• Cosmetic & Personal Care Ingredients: Acts as a high-purity emollient and conditioning agent in premium skincare formulations, valued for its stability and skin-compatible properties.
• Synthetic Chemistry Intermediate: A crucial building block for the synthesis of more complex phospholipids (like phosphatidylcholines) and other functionalized glycerolipids.
• Food Science Research: Employed in studies related to fat digestion, absorption, and the metabolic effects of specific dietary glycerides.

Basic Information

Product Name	1,2-Distearoyl-Sn-Glycerol
CAS No.	1429-59-0
Molecular Formula	C39H76O5
Molecular Weight	625.02 g/mol
Synonyms	1,2-Di-O-stearoyl-sn-glycerol; sn-Glycerol 1,2-distearate; (2S)-1,2-Distearoyloxy-3-hydroxypropane; 1,2-Distearin; 1,2-Di-O-stearoylglycerol; DG(18:0/18:0); Distearoyl glycerol; 1,2-Distearoyl-sn-glycerol
EINECS	215-857-8

Quality Control

Our 1,2-Distearoyl-Sn-Glycerol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chromatographic purity assays and identity confirmation, to ensure it meets the stringent requirements for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatograms and specifications are provided for every lot, supporting compliance with cGMP and ISO 9001 standards where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C or as indicated on the label or COA. For long-term storage under inert atmosphere, seal under argon or nitrogen. The product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
1,3-Distearoyl Isomer (HPLC)	≤ 1.0%
Monostearoyl Glycerol (HPLC)	≤ 0.5%
Tristearoyl Glycerol (HPLC)	≤ 0.5%
Free Fatty Acid (as Stearic Acid)	≤ 0.1%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.