Description

1,2-Cyclopropanedicarbonyl Chloride, 3-Methylene- (6Ci) is a highly reactive, functionalized cyclopropane derivative that serves as a versatile building block in advanced organic synthesis. Its unique strained-ring structure and dual acyl chloride functionality make it a critical intermediate for constructing complex molecular architectures. This compound is particularly valuable for researchers and process chemists in the pharmaceutical and agrochemical industries, where it is used to introduce the cyclopropane moiety, a key pharmacophore known to enhance metabolic stability and modulate biological activity.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) containing cyclopropane rings, such as protease inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the cyclopropane group can improve compound efficacy and environmental profile.
• Material Science Monomer: Serves as a precursor for specialty polymers and resins, contributing to unique thermal and mechanical properties in the final materials.
• Ligand and Catalyst Development: Employed in the synthesis of novel chiral ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized to create molecular probes and labeled compounds for studying biological pathways and protein interactions.
• Academic & R&D: A valuable reagent for methodological development and exploring new reaction pathways in organic chemistry laboratories.

Basic Information

Product Name	1,2-Cyclopropanedicarbonyl Chloride, 3-Methylene- (6Ci)
CAS No.	98141-48-1
Molecular Formula	C7H6Cl2O2
Molecular Weight	193.03 g/mol
Synonyms	3-Methylene-1,2-cyclopropanedicarbonyl dichloride; 3-Methylenecyclopropane-1,2-dicarbonyl dichloride; 1,2-Cyclopropanedicarbonyl dichloride, 3-methylene-; 3-Methylenebicyclo[1.1.0]butane-2,4-dicarbonyl dichloride; 3-Methylenecyclopropane-1,2-dicarboxylic acid dichloride; 3-Methylenebicyclo[1.1.0]butane-2,4-dicarboxylic acid dichloride
EINECS	Contact for details

Quality Control

Our 1,2-Cyclopropanedicarbonyl Chloride, 3-Methylene- (6Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures the material is suitable for demanding applications in cGMP and research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.