Description

3,3-Dimethylbutyryl Chloride is a versatile and highly reactive acid chloride derivative of pivalic acid. This compound serves as a critical building block in organic synthesis, enabling the efficient introduction of the bulky, lipophilic 3,3-dimethylbutyryl moiety. It is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to synthesize active ingredients, advanced intermediates, and specialty fine chemicals requiring sterically hindered acyl groups.

Application

• Pharmaceutical Intermediate: Key reagent for the synthesis of active pharmaceutical ingredients (APIs), particularly in the production of prodrugs and compounds designed for enhanced metabolic stability.
• Agrochemical Synthesis: Used in the manufacture of pesticides, herbicides, and fungicides where the tert-butyl-like structure can improve compound lipophilicity and biological activity.
• Peptide Chemistry: Employed as an acylating agent for the protection of amino groups or the synthesis of modified peptides.
• Polymer Chemistry: Acts as a monomer or modifying agent in the production of specialty polymers, including polyamides and polyesters with unique thermal and mechanical properties.
• Ligand and Catalyst Development: Useful for preparing specialized ligands used in asymmetric catalysis and organometallic chemistry.
• Flavor and Fragrance Industry: Serves as a precursor for synthesizing esters and other compounds that contribute to specific flavor or fragrance profiles.
• Material Science Research: Applied in surface modification and the creation of functionalized materials for research and development.

Basic Information

Product Name	3,3-Dimethylbutyryl Chloride
CAS No.	7065-46-5
Molecular Formula	C6H11ClO
Molecular Weight	134.60 g/mol
Synonyms	Pivaloyl Chloride, 2,2-Dimethylpropionyl Chloride; Trimethylacetyl Chloride; 3,3-Dimethylbutanoyl Chloride; NSC 8425; Butanoyl chloride, 3,3-dimethyl-; tert-Butylacetyl Chloride; 2,2-Dimethylpropanoic Acid Chloride
EINECS	230-377-3

Quality Control

Our 3,3-Dimethylbutyryl Chloride is produced under strict quality management systems. Every batch undergoes comprehensive analytical testing, including GC, NMR, and titration methods, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP manufacturing for pharmaceutical applications and can provide documentation for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from heat, ignition sources, and incompatible materials such as strong bases, alcohols, and amines. Due to its nature as a strong acid/organic solvent and highly volatile compound, storage temperature is recommended at 2-8°C (refrigerated) for long-term stability. Allow the container to reach room temperature before opening to prevent moisture ingress.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Purity (GC Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Acid Value	Contact for details
Density (at 20°C)	~1.00 g/mL
Boiling Point	~105-107°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.