Description

Lipoxin B4 is a specialized lipoxin, a class of potent bioactive lipid mediators derived from arachidonic acid. It plays a critical role as a pro-resolving signaling molecule, actively promoting the resolution of inflammation and tissue homeostasis. This high-purity compound is essential for researchers and developers in the pharmaceutical, biotechnology, and advanced life science sectors, particularly for applications in immunology, inflammation research, and the development of novel therapeutic agents.

Application

• Biomedical Research: A key reference standard and active agent for studying the molecular mechanisms of inflammation resolution, cellular signaling pathways, and immune modulation.
• Drug Discovery & Development: Serves as a lead compound or biochemical tool for screening and developing new anti-inflammatory and pro-resolving therapeutic candidates.
• In Vitro & In Vivo Studies: Used in cell culture assays and animal models to investigate its effects on neutrophil and macrophage function, cytokine production, and tissue repair processes.
• Analytical Standard: Critical for the qualitative and quantitative analysis (e.g., via LC-MS/MS, ELISA) of lipoxin pathways in biological samples for diagnostic and research purposes.
• Biochemical Reagent: Employed in enzymatic studies and receptor binding assays to elucidate the structure-activity relationships of specialized pro-resolving mediators (SPMs).

Basic Information

Product Name	Lipoxin B4
CAS No.	98049-69-5
Molecular Formula	C20H32O5
Molecular Weight	352.47 g/mol
Synonyms	Lipoxin B4; LXB4; (5S,14R,15S)-5,6,15-Trihydroxy-7,9,11,13-eicosatetraenoic acid; 5(S),14(R),15(S)-Trihydroxy-6,8,10,12-eicosatetraenoic acid; 5S,14R,15S-Trihydroxy-6E,8Z,10E,12E-eicosatetraenoic acid; (6E,8Z,10E,12E)-(5S,14R,15S)-5,14,15-Trihydroxyicosa-6,8,10,12-tetraenoic acid
EINECS	Contact for details

Quality Control

Our Lipoxin B4 is produced and handled under strict quality-controlled conditions to ensure batch-to-batch consistency and high chemical purity suitable for research applications. Each lot is accompanied by comprehensive analytical documentation. Certificates of Analysis (COA) detailing purity, identity confirmation, and impurity profiles are available upon request to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Solubility	Soluble in ethanol, DMSO; slightly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.