Description

1-25-Dihydroxy-23,23-Difluorovitamin D3 is a fluorinated analog of calcitriol, the active form of Vitamin D3, designed for enhanced metabolic stability and targeted biological activity. This compound is of significant interest for advanced pharmaceutical research and development due to its potential to modulate vitamin D receptor (VDR) signaling with improved pharmacokinetic profiles. It serves as a critical intermediate and reference standard for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those developing novel therapeutics for bone disorders, immune modulation, and oncology.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of next-generation Vitamin D analogs and prodrugs.
• Biochemical Research: Used as a high-purity reference standard in metabolic pathway studies and VDR binding affinity assays.
• Drug Discovery & Development: Critical for preclinical research targeting diseases related to calcium homeostasis, such as osteoporosis and secondary hyperparathyroidism.
• Academic Research: Employed in universities and research institutes for studying the structure-activity relationships (SAR) of fluorinated secosteroids.
• Analytical Standard: Serves as a certified reference material (CRM) for quality control and method validation in analytical laboratories (HPLC, LC-MS).

Basic Information

Product Name	1-25-Dihydroxy-23,23-Difluorovitamin D3
CAS No.	98040-59-6
Molecular Formula	C₂₇H₄₂F₂O₃
Molecular Weight	452.62 g/mol
Synonyms	1α,25-Dihydroxy-23,23-difluorovitamin D3; 23,23-Difluoro-1α,25-dihydroxyvitamin D3; 23,23-Difluoro-1α,25-dihydroxycholecalciferol; Falecalcitriol Impurity; 1α,25-Dihydroxy-23,23-difluoro-9,10-secocholesta-5,7,10(19)-trien-3β-ol; (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4R)-4,6-Difluoro-5-hydroxy-1-methylhept-2-en-1-yl]-7a-methyloctahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
EINECS	Contact for details

Quality Control

Our 1-25-Dihydroxy-23,23-Difluorovitamin D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for research and pharmaceutical development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, cool place. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.