Description

10,11,12-Trihydroxy-5,8,14,17-Eicosatetraenoic Acid is a specialized polyhydroxy fatty acid derivative, also known as a trihydroxyeicosatetraenoic acid (TriHETE), which serves as a key intermediate and reference standard in advanced biochemical research. This compound is valued for its role in studying lipid signaling pathways, inflammation, and oxidative stress responses. It is primarily utilized by research institutions, pharmaceutical R&D departments, and manufacturers of high-purity biochemical reagents.

Application

• Biochemical Research Standard: Used as a high-purity reference material in analytical laboratories for method development and validation in lipidomics.
• Pharmaceutical R&D: Acts as a critical intermediate or a biological probe in the development of novel therapeutics targeting inflammatory and metabolic disorders.
• Cell Signaling Studies: Employed in in-vitro research to investigate the mechanisms of eicosanoid-mediated pathways and cellular responses.
• Enzyme Substrate: Serves as a substrate for studies involving lipoxygenase, cytochrome P450, and other enzymes involved in arachidonic acid metabolism.
• Analytical Chemistry: Used to calibrate equipment (e.g., HPLC, LC-MS) for the accurate quantification of related hydroxy fatty acids in complex matrices.

Basic Information

Product Name	10,11,12-Trihydroxy-5,8,14,17-Eicosatetraenoic Acid
CAS No.	98004-40-1
Molecular Formula	C₂₀H₃₂O₅
Molecular Weight	352.47 g/mol
Synonyms	10,11,12-TriHETE; (5Z,8Z,14Z,17Z)-10,11,12-Trihydroxyicosa-5,8,14,17-tetraenoic Acid; 10,11,12-Trihydroxyeicosatetraenoic Acid; 10,11,12-Trihydroxy-5Z,8Z,14Z,17Z-eicosatetraenoic Acid; Trihydroxy Eicosatetraenoic Acid; 10,11,12-Trihydroxyarachidonic Acid Derivative
EINECS	Contact for details

Quality Control

Every batch of 10,11,12-Trihydroxy-5,8,14,17-Eicosatetraenoic Acid is manufactured and analyzed under strict quality management systems to ensure identity, purity, and consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the product to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Water Content	≤ 1.0% (KF)
Residue on Ignition	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.