Description

1,23-Dihydroxy-24,25,26,27-Tetranorvitamin D3 is a biologically active metabolite of vitamin D, playing a crucial role in calcium and phosphate homeostasis. This compound is valued for its high purity and stability, making it an essential reference standard and key intermediate in advanced pharmaceutical research and development. It is primarily utilized by research institutions and pharmaceutical companies focused on developing novel therapeutics for bone metabolism disorders, renal diseases, and endocrine research.

Application

• Pharmaceutical Reference Standard: Used for the calibration of analytical instruments and the validation of assay methods in quality control laboratories.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a critical synthetic precursor in the manufacture of advanced vitamin D analogs and related drugs.
• Biochemical Research: Employed in in-vitro and in-vivo studies to investigate the non-classical pathways of vitamin D metabolism and signaling.
• Metabolite Analysis: Acts as a standard for the quantification of vitamin D metabolites in biological samples via LC-MS/MS or HPLC.
• Drug Discovery & Development: Utilized in high-throughput screening and preclinical studies to evaluate new compounds targeting vitamin D receptors.

Basic Information

Product Name	1,23-Dihydroxy-24,25,26,27-Tetranorvitamin D3
CAS No.	97903-37-2
Molecular Formula	C₂₃H₃₄O₃
Molecular Weight	358.51 g/mol
Synonyms	1,23-Dihydroxytetranorvitamin D3; 1,23-Dihydroxy-24,25,26,27-tetranor-cholecalciferol; 1α,23(S),25-Trihydroxy-24,26,27-trinorvitamin D3; 1α,23(S),25-Trihydroxy-24,26,27-trinor-cholecalciferol; Tetranor-1,23-(OH)2-D3; Vitamin D3 metabolite 1,23-(OH)2-24,25,26,27-tetranor
EINECS	Contact for details

Quality Control

Our 1,23-Dihydroxy-24,25,26,27-Tetranorvitamin D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with relevant standards.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) or as specified on the label or COA. This product is light-sensitive and easily oxidized; prolonged exposure to air, light, or elevated temperatures should be avoided to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.