Description

n-Succinyl-1,2-Dioleoylphosphatidylethanolamine is a functionalized phospholipid derivative, specifically a succinylated phosphatidylethanolamine (PE). This compound matters as a key intermediate and functional component in advanced drug delivery systems, particularly for creating pH-sensitive liposomes and targeted nanoparticles. It is primarily needed by pharmaceutical R&D teams, formulation scientists, and manufacturers in the liposome, nanomedicine, and diagnostic reagent sectors.

Application

• pH-Sensitive Liposome Formulation: As a critical component for creating liposomes that release their cargo in response to acidic environments, such as tumor tissues or endosomes.
• Targeted Drug Delivery Systems: Used to functionalize nanoparticle surfaces for active targeting, often by conjugating ligands (e.g., antibodies, peptides) to the free carboxyl group of the succinyl moiety.
• Long-Circulating Nanocarriers: A building block for PEGylated or stealth lipid nanoparticles to improve blood circulation time and reduce immune clearance.
• Diagnostic Imaging Agents: Incorporation into lipid-based carriers for contrast agents in MRI, ultrasound, or fluorescence imaging.
• Gene Delivery: As a helper lipid in non-viral vector formulations for the delivery of DNA, siRNA, or mRNA.
• Bioconjugation & Surface Modification: The reactive succinyl group provides a handle for covalent attachment of various biomolecules to lipid membranes.
• Model Membrane Studies: Used in biophysical research to study membrane fusion, permeability, and protein-lipid interactions.
• Cosmetic & Dermal Delivery: Potential use in advanced cosmetic formulations for the encapsulation and targeted delivery of active ingredients.

Basic Information

Product Name	n-Succinyl-1,2-Dioleoylphosphatidylethanolamine
CAS No.	97782-02-0
Molecular Formula	C49H90NO10P
Molecular Weight	884.21 g/mol
Synonyms	Succinyl-DOPE; N-Succinyl-DOPE; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-N-succinate; S-DOPE; N-Succinyl-1,2-dioleoyl-sn-glycero-3-phosphoethanolamine; Succinyl phosphatidylethanolamine (DOPE-based); N-(Succinyl)-DOPE; PE-N-Succinate (DOPE)
EINECS	Contact for details

Quality Control

Our n-Succinyl-1,2-Dioleoylphosphatidylethanolamine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, identity, and consistency. We provide comprehensive Certificates of Analysis (COA) that include data from HPLC, NMR, and MS analysis. Specifications are designed to meet the stringent requirements of pharmaceutical research and GLP/GMP environments.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below under an inert atmosphere (argon or nitrogen). This product is hygroscopic (moisture-sensitive) and easily oxidized. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. Once opened, purge the container with inert gas and reseal immediately.

Specification

Item	Specification
Appearance	White to off-white waxy solid or film
Identification (HPLC/MS)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 1.0%
Peroxide Value	≤ 5.0 meq/kg
Phase Transition Temperature (DSC)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.