Description

1-[[3-(Trifluoromethyl)Phenyl]Sulfonyl]Piperazine is a high-value, functionalized piperazine derivative characterized by a sulfonyl linker and a trifluoromethylphenyl group, offering unique electronic and steric properties for advanced synthesis. This compound serves as a critical pharmaceutical intermediate and building block in the development of novel active ingredients, particularly in medicinal chemistry. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for creating molecules with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, especially kinase inhibitors, receptor antagonists, and central nervous system (CNS) active compounds.
• Agrochemical Research: Used as a building block for developing new herbicides, fungicides, and insecticides that leverage the trifluoromethyl group for improved lipophilicity and efficacy.
• Material Science: Employed in the research and development of advanced polymers, ligands for catalysis, and specialty materials requiring specific sulfonamide functionalities.
• Chemical Biology Probe Synthesis: Useful for creating molecular probes and tool compounds to study biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up processes.

Basic Information

Product Name	1-[[3-(Trifluoromethyl)Phenyl]Sulfonyl]Piperazine
CAS No.	97630-01-8
Molecular Formula	C11H13F3N2O2S
Molecular Weight	294.29 g/mol
Synonyms	1-[(3-Trifluoromethyl)benzenesulfonyl]piperazine; 1-[(3-Trifluoromethyl)phenyl]sulfonyl-piperazine; 1-(3-Trifluoromethylphenylsulfonyl)piperazine; N-(3-Trifluoromethylphenylsulfonyl)piperazine; Piperazine, 1-[[3-(trifluoromethyl)phenyl]sulfonyl]-; 3-(Trifluoromethyl)benzenesulfonamide, N-(1-piperazinyl)-; 97630-01-8
EINECS	Contact for details

Quality Control

Our 1-[[3-(Trifluoromethyl)Phenyl]Sulfonyl]Piperazine is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development as well as scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.