Description

1,25-Dihydroxy-26,27-Dimethylcholecalciferol is a potent synthetic analog of the active form of vitamin D, specifically engineered with methyl groups at the 26 and 27 positions. This structural modification enhances its metabolic stability and biological activity, making it a critical compound for advanced research and development. It is primarily sought after by pharmaceutical researchers and fine chemical manufacturers focused on endocrinology, oncology, and metabolic bone disease studies.

Application

• Pharmaceutical Research & Development: A key reference standard and active pharmaceutical ingredient (API) intermediate for investigating vitamin D receptor (VDR) agonists and antagonists.
• Biochemical Studies: Used in cell culture and in vitro assays to study calcium and phosphate homeostasis, cell differentiation, and immune modulation.
• Preclinical Development: Serves as a lead compound for developing novel therapeutics targeting osteoporosis, psoriasis, and secondary hyperparathyroidism.
• Chemical Synthesis: An advanced intermediate for the synthesis of other high-value, structurally modified vitamin D analogs.
• Reference Material: Employed as a high-purity calibrant in analytical laboratories for method development and quality control of related compounds.

Basic Information

Item	Detail
Product Name	1,25-Dihydroxy-26,27-Dimethylcholecalciferol
CAS No.	97473-92-2
Molecular Formula	C₂₉H₄₆O₃
Molecular Weight	442.68 g/mol
Synonyms	1,25-Dihydroxy-26,27-dimethylvitamin D₃; 26,27-Dimethyl-1,25-dihydroxycholecalciferol; 26,27-Dimethylcalcitriol; 1α,25-Dihydroxy-26,27-dimethylcholesta-5,7,10(19)-trien-3β-ol; Ro 23-8522; KH 1060 (a closely related analog, often referenced); EB 1089 (a closely related analog, often referenced)
EINECS	Contact for details

Quality Control

Our 1,25-Dihydroxy-26,27-Dimethylcholecalciferol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets exacting standards for research and development use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay, and related substance profiles.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the container to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference spectrum
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.