Description

25-Hydroxy-6,19-Epoxyvitamin D3 is a synthetic vitamin D analog and a key intermediate in the research and development of calcitriol-related compounds. This compound matters for its role in studying vitamin D receptor (VDR) signaling pathways and the synthesis of novel therapeutic agents targeting bone metabolism and cell differentiation. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of advanced active pharmaceutical ingredients (APIs) for metabolic and endocrine disorders.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of novel vitamin D analogs and active pharmaceutical ingredients (APIs) targeting calcium homeostasis.
• Biochemical Research: Used as a reference standard and tool compound in studies of vitamin D metabolism, VDR activation, and gene regulation.
• Drug Discovery: Serves as a building block for developing new therapeutic agents for osteoporosis, psoriasis, and secondary hyperparathyroidism.
• Academic & Clinical Studies: Employed in metabolic pathway analysis and the investigation of vitamin D's role in immune modulation and cellular proliferation.
• Analytical Standard: Provides a high-purity standard for quality control (QC) and analytical method development (e.g., HPLC, LC-MS) in pharmaceutical manufacturing.

Basic Information

Product Name	25-Hydroxy-6,19-Epoxyvitamin D3
CAS No.	96999-68-7
Molecular Formula	C₂₇H₄₂O₃
Molecular Weight	414.62 g/mol
Synonyms	6,19-Epoxy-25-hydroxyvitamin D3; (5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-3β,25-diol, 6,19-epoxy-; 25-Hydroxy-6,19-epidioxyvitamin D3; 25(OH)-6,19-EpoxyVD3; Vitamin D3 analog intermediate; 1α,25-Dihydroxyvitamin D3 analog precursor
EINECS	Contact for details

Quality Control

Our 25-Hydroxy-6,19-Epoxyvitamin D3 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets high-purity standards suitable for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical methods is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term stability, storing under an inert atmosphere (e.g., argon or nitrogen) in a freezer (-20°C) is recommended. Keep away from strong oxidizers.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solvent Residues (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.