Description

4,7,10,13,16,19-Docosahexaenoic Acid, (1R)-1-[[[(2-Aminoethoxy)Hydroxyphosphinyl]Oxy]Methyl]-2-[(1-Oxohexadecyl)Oxy]Ethyl Ester, (4Z,7Z,10Z,13Z,16Z,19Z)- is a specialized, high-purity phospholipid derivative of docosahexaenoic acid (DHA). This compound is engineered to enhance the bioavailability and targeted delivery of the essential ω-3 fatty acid DHA, which is critical for neurological and cellular membrane function. It is primarily utilized by advanced pharmaceutical and nutraceutical manufacturers for the development of innovative lipid-based drug delivery systems, parenteral nutrition formulations, and high-efficacy dietary supplements.

Application

• Pharmaceutical Drug Delivery: As a key phospholipid excipient in liposomal, nanoemulsion, and other advanced delivery platforms for poorly soluble active pharmaceutical ingredients (APIs).
• Parenteral Nutrition: A vital component in intravenous lipid emulsions (ILE) to provide essential fatty acids and energy to patients unable to consume food orally.
• High-Potency Nutraceuticals: Used in premium dietary supplements designed for superior cognitive and cardiovascular support due to its enhanced bioavailability profile.
• Biomedical Research: Serves as a critical reagent in lipidomics research, membrane biophysics studies, and the development of cellular models.
• Cosmeceuticals: Incorporated into advanced skincare formulations for its membrane-stabilizing and anti-inflammatory properties.
• Functional Food Fortification: For the enrichment of foods and beverages with a stable, bioavailable form of ω-3 DHA.

Basic Information

Item	Details
Product Name	4,7,10,13,16,19-Docosahexaenoic Acid, (1R)-1-[[[(2-Aminoethoxy)Hydroxyphosphinyl]Oxy]Methyl]-2-[(1-Oxohexadecyl)Oxy]Ethyl Ester, (4Z,7Z,10Z,13Z,16Z,19Z)-
CAS No.	96998-00-4
Molecular Formula	C47H84NO9P
Molecular Weight	838.15 g/mol
Synonyms	DHA Phospholipid Derivative; 1-Hexadecanoyl-2-docosahexaenoyl-sn-glycero-3-phosphoethanolamine; DHA-PE; DHA-Phosphatidylethanolamine; (4Z,7Z,10Z,13Z,16Z,19Z)-Docosa-4,7,10,13,16,19-hexaenoic acid 2-[(1-oxohexadecyl)oxy]-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]ethyl ester; 1-Palmitoyl-2-docosahexaenoyl-phosphatidylethanolamine; PE(16:0/22:6); Phosphatidylethanolamine (16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z))
EINECS	Contact for details

Quality Control

Our production of this high-purity phospholipid adheres to strict cGMP guidelines to ensure batch-to-batch consistency and reliability for critical applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and isomer profile, NMR for structural confirmation, and GC for fatty acid composition. A detailed Certificate of Analysis (COA) documenting identity, purity, and critical impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store unopened containers at -20°C under an inert atmosphere (argon or nitrogen). Once opened, use promptly and minimize exposure to air, heat, and moisture. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Yellow to pale orange waxy solid or oil
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
DHA Isomer Profile (GC)	≥ 98% all-cis (4Z,7Z,10Z,13Z,16Z,19Z)
Peroxide Value	≤ 5.0 meq/kg
Heavy Metals (as Pb)	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines
Microbial Limits	Meets USP <61> and <62>

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.