Description

Corticosterone 21-Oleate is a specific ester derivative of the endogenous glucocorticoid corticosterone, where the 21-hydroxyl group is conjugated with oleic acid. This chemical modification is significant for research into lipophilic steroid prodrugs, altering the compound's solubility, bioavailability, and metabolic pathway. It serves as a critical reference standard and biochemical tool for scientists in pharmaceutical R&D and analytical laboratories investigating steroid metabolism, prodrug design, and lipid conjugation strategies.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis of corticosterone derivatives in method development and quality control (QC/QA) for pharmaceutical products.
• Biochemical Research: Acts as a key intermediate or model compound in studies focused on steroid esterification, lipophilicity, and targeted drug delivery systems.
• Metabolic Pathway Investigation: Employed in research to understand the hydrolysis, distribution, and activity of esterified steroid hormones in biological systems.
• Prodrug Development: Serves as a prototype molecule for designing and evaluating novel lipophilic prodrugs of corticosteroids to enhance dermal absorption or modify release profiles.
• Analytical Method Development: Utilized as a high-purity calibrant in chromatographic techniques (HPLC, LC-MS) for detecting and quantifying related steroid esters in complex matrices.

Basic Information

Product Name	Corticosterone 21-Oleate
CAS No.	96913-12-1
Molecular Formula	C39H62O4
Molecular Weight	594.9 g/mol
Synonyms	11β,21-Dihydroxypregn-4-ene-3,20-dione 21-oleate; Corticosterone 21-(9Z-octadecenoate); 21-Oleoyloxycorticosterone; Corticosterone oleic acid ester; (11β)-11,21-Dihydroxypregn-4-ene-3,20-dione 21-(9Z)-9-octadecenoate
EINECS	Contact for details

Quality Control

Our Corticosterone 21-Oleate is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing results from advanced techniques such as HPLC, NMR, and mass spectrometry. Our quality commitment ensures the material meets the exacting standards required for pharmaceutical research and analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the certificate of analysis. The compound is light-sensitive; prolonged exposure should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.