Description

Macrogol-Poly(Vinyl Alcohol) Graft-Copolymer is a synthetic, amphiphilic polymer designed for advanced formulation applications. This unique graft-copolymer structure combines the hydrophilic properties of poly(vinyl alcohol) with the flexible, biocompatible nature of polyethylene glycol (PEG/Macrogol) chains. It is particularly valued for its ability to act as a solubilizer, stabilizer, and matrix former in complex delivery systems. Key industries that utilize this specialty polymer include pharmaceuticals, cosmetics, and advanced material science.

Application

• Pharmaceutical Solubilization: Enhances the aqueous solubility and bioavailability of poorly soluble active pharmaceutical ingredients (APIs).
• Ophthalmic & Topical Formulations: Serves as a viscosity enhancer, lubricant, and film-forming agent in eye drops, gels, and creams.
• Controlled Drug Delivery: Used as a matrix or coating material in tablets, microparticles, and implants for sustained or targeted release.
• Cosmetic & Personal Care: Functions as a stabilizer, thickener, and sensory modifier in lotions, serums, and hair care products.
• Nanoparticle Stabilization: Acts as a steric stabilizer or surface modifier for polymeric and lipid nanoparticles to prevent aggregation.
• Adhesive & Coating Additive: Imparts flexibility, moisture resistance, and adhesion properties in specialty coatings and adhesives.

Basic Information

Product Name	Macrogol-Poly(Vinyl Alcohol) Graft-Copolymer
CAS No.	96734-39-3
Molecular Formula	(C2H4O)n.(C2H4O)m - Complex copolymer
Molecular Weight	Variable (Typically 10,000 - 200,000 g/mol)
Synonyms	PEG-PVA Graft Copolymer; Polyethylene glycol-graft-poly(vinyl alcohol); PEG-g-PVA; Poly(ethylene glycol)-co-poly(vinyl alcohol); Macrogol 6000/PVA Copolymer; Poly(oxyethylene)-graft-poly(vinyl alcohol); PVA-PEG Graft Polymer; Kollicoat IR (related trade product)
EINECS	Contact for details

Quality Control

Our Macrogol-Poly(Vinyl Alcohol) Graft-Copolymer is manufactured under a quality management system. Each batch is tested to ensure consistent performance characteristics such as molecular weight distribution, grafting efficiency, and residual monomer content. Certificates of Analysis (COA) detailing specific parameters are available upon request. We can support development of specifications aligned with cGMP, ICH Q3, and relevant pharmacopeial guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after initial use to minimize moisture absorption, which can affect physical properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or granules
Identification (IR)	Complies
Assay (PEG/PVA Ratio)	As per customer grade
Molecular Weight (GPC)	Specified range
Loss on Drying	≤ 5.0 %
Residual Solvents (GC)	Meets ICH limits
Residual Monomer (VAc)	≤ 0.1 %
pH (in solution)	5.0 - 7.0

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.