Description

Poly(D,L-Lactide-Co-Glycolide) is a biodegradable and biocompatible copolymer widely used in advanced pharmaceutical and biomedical applications. Its controlled degradation profile and tunable properties make it an essential material for sustained-release drug delivery systems. This polymer is primarily needed by manufacturers in the pharmaceutical, medical device, and advanced biomaterials industries.

Application

• Controlled-Release Injectable Formulations: As the primary excipient for long-acting depot injections (e.g., microspheres, implants).
• Surgical Sutures and Medical Devices: For manufacturing biodegradable sutures, meshes, and tissue engineering scaffolds.
• Nanoparticle and Microparticle Drug Delivery: Encapsulation of active pharmaceutical ingredients (APIs) for targeted and sustained release.
• Tissue Engineering: As a matrix material for 3D scaffolds in regenerative medicine.
• Veterinary Medicine: Development of long-acting parenteral formulations for animal health.
• Research & Development: Prototyping novel drug delivery systems and studying polymer degradation kinetics.

Basic Information

Product Name	Poly(D,L-Lactide-Co-Glycolide)
CAS No.	26780-50-7
Molecular Formula	(C3H4O2)m(C6H8O4)n
Molecular Weight	Varies by lactide:glycolide ratio and inherent viscosity
Synonyms	PLGA; Poly(lactic-co-glycolic acid); Poly(DL-lactide-co-glycolide); DL-PLGA; Resomer® RG (series); Lactel® (various grades); DL-PLG; Poly(D,L-lactic acid-co-glycolic acid); (3S-cis)-3,6-Dimethyl-1,4-dioxane-2,5-dione polymer with 1,4-dioxane-2,5-dione
EINECS	Contact for details

Quality Control

Our Poly(D,L-Lactide-Co-Glycolide) is manufactured under strict quality systems suitable for pharmaceutical development. Each batch is characterized for critical parameters including inherent viscosity, lactide:glycolide (L:G) ratio, molecular weight distribution, and residual monomers. Certificates of Analysis (COA) are provided, detailing specifications and test results. We support development with grades suitable for research through to GMP-compliant production.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive). Allow the sealed container to reach room temperature before opening to prevent condensation and moisture uptake. Store in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder or granules
Identification (IR)	Conforms to reference spectrum
Lactide:Glycolide Ratio (NMR)	50:50, 65:35, 75:25, 85:15 (or as specified)
Inherent Viscosity (dl/g)	0.15 - 1.2 (or as specified per grade)
Molecular Weight (Mw)	5,000 - 100,000 Da (grade dependent)
Residual Monomers (HPLC)	< 0.5% (Lactide & Glycolide)
Residual Solvents (GC)	Meets ICH Q3C guidelines
Glass Transition Temp (DSC)	40°C - 55°C (grade dependent)
Moisture Content (KF)	< 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.