Description

n-Methyl-1,2-Dioleoylphosphatidylethanolamine is a synthetic, methylated phospholipid derivative widely used in advanced formulation science. This compound is valued for its role as a key functional excipient and structural component in creating stable, targeted delivery systems. It is essential for research and development teams in the pharmaceutical, biotechnology, and advanced material science sectors seeking to engineer sophisticated lipid-based carriers.

Application

• Lipid Nanoparticle (LNP) Formulation: A critical structural lipid component for the development of mRNA and siRNA delivery systems, enhancing stability and cellular uptake.
• Liposome & Niosome Preparation: Used to modify membrane fluidity and surface charge in vesicle-based drug delivery platforms for improved encapsulation efficiency and targeted release.
• Gene Therapy Research: Serves as a functional helper lipid in non-viral vector systems to facilitate nucleic acid complexation and endosomal escape.
• Cosmetic Actives Delivery: Employed in high-performance cosmetic formulations to create nanocarriers for the stable and efficient delivery of active ingredients into the skin.
• Biomimetic Membrane Studies: Utilized in model membrane systems (e.g., supported lipid bilayers) for biophysical research and membrane protein studies.
• Diagnostic Reagent Development: Incorporated into the formulation of contrast agents and fluorescent probes for diagnostic imaging applications.

Basic Information

Product Name	n-Methyl-1,2-Dioleoylphosphatidylethanolamine
CAS No.	96687-23-9
Molecular Formula	C44H84NO8P
Molecular Weight	786.10 g/mol
Synonyms	1,2-Dioleoyl-sn-glycero-3-phospho-N-methylethanolamine; DOPE-N-methyl; N-Methyl-DOPE; Methyl-PE (18:1); Phosphatidylethanolamine-N-methyl (dioleoyl); N-Methyl-1,2-dioleoyl-sn-glycero-3-phosphoethanolamine; (2R)-2,3-Bis[[(Z)-octadec-9-enoyl]oxy]propyl 2-(methylamino)ethyl hydrogen phosphate
EINECS	Contact for details

Quality Control

Our n-Methyl-1,2-Dioleoylphosphatidylethanolamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for research and formulation. Certificates of Analysis (COA) detailing specific batch results are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white waxy solid or oil
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (TLC)	Single major spot
Solubility	Soluble in chloroform, ethanol; insoluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.