Description

(S)-Hexahydro-Pyrrolo[1,2-A]Pyrazin-1-One is a high-purity chiral building block and pharmaceutical intermediate of significant commercial and research interest. This compound is valued for its rigid, bicyclic structure which serves as a key scaffold in the synthesis of bioactive molecules, particularly in medicinal chemistry. It is primarily needed by pharmaceutical R&D laboratories, contract development and manufacturing organizations (CDMOs), and fine chemical suppliers focused on developing novel therapeutics, including central nervous system (CNS) agents and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A critical chiral scaffold in the synthesis of potential drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used as a building block for constructing complex molecular libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Asymmetric Synthesis: Employed in chiral pool synthesis and as a precursor for catalysts or ligands due to its defined stereochemistry at the (S)-configuration.
• API Development: Serves as a key intermediate in the development of Active Pharmaceutical Ingredients (APIs), particularly for neurological and psychiatric disorders.
• Biochemical Tool Compound: May be utilized in biochemical assays to study enzyme mechanisms or receptor interactions.
• Academic & Industrial R&D: Fundamental research in organic synthesis and the development of new synthetic methodologies.

Basic Information

Product Name	(S)-Hexahydro-Pyrrolo[1,2-A]Pyrazin-1-One
CAS No.	96145-91-4
Molecular Formula	C7H12N2O
Molecular Weight	140.18 g/mol
Synonyms	(S)-Octahydropyrrolo[1,2-a]pyrazin-1-one; (S)-1,2,3,4,5,6,7,8-Octahydropyrrolo[1,2-a]pyrazin-1-one; (S)-Hexahydro-1H-pyrrolo[1,2-a]pyrazin-1-one; (S)-Perhydropyrrolo[1,2-a]pyrazin-1-one; (S)-Pyrrolo[1,2-a]pyrazin-1-one, hexahydro-; (S)-1-Oxohexahydropyrrolo[1,2-a]pyrazine; (S)-HPP; (S)-Enantiomer of Hexahydropyrrolo[1,2-a]pyrazin-1-one
EINECS	Contact for details

Quality Control

Our (S)-Hexahydro-Pyrrolo[1,2-A]Pyrazin-1-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with exacting standards for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity (HPLC), chiral excess, and impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). For long-term storage, consider storing under an inert atmosphere to maintain optimal stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.