Description

Nicotine Polacrilex is a pharmaceutical-grade ion-exchange resin complex designed for the controlled delivery of nicotine. This advanced formulation is critical for ensuring consistent dosing and enhancing product stability in various delivery systems. It is primarily utilized by manufacturers in the pharmaceutical and consumer healthcare industries for the development of nicotine replacement therapies (NRTs), such as gums and lozenges, to aid in smoking cessation.

Application

• Nicotine Replacement Therapy (NRT) Products: The primary active ingredient in over-the-counter (OTC) nicotine polacrilex gum and lozenges for smoking cessation.
• Pharmaceutical Formulations: Used in controlled-release oral dosage forms where a steady release profile of nicotine is required.
• Consumer Healthcare: A key component in the development of modern, convenient, and discreet nicotine delivery systems.
• Drug Delivery Research: Serves as a model ion-exchange resin for studying controlled release mechanisms for cationic active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Nicotine Polacrilex
CAS No.	96055-45-7
Molecular Formula	(C10H14N2)n • (C9H10O2)m
Molecular Weight	Polymeric complex (Contact for details)
Synonyms	Nicotine Polacrilex Resin; Nicotine Ion-Exchange Resin; Nicotine-Polyacrylic Acid Resin Complex; Amberlite® IRP64 Nicotine Complex; Nicotine Resinate; Polacrilex Nicotine; Nicotine Polacrilin; Nicotine exchange resin
EINECS	Contact for details

Quality Control

Our Nicotine Polacrilex is manufactured under strict quality management systems. Each batch is tested to ensure it meets stringent specifications for pharmaceutical applications, including identity, assay, and impurity profiles. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing results against relevant pharmacopeial standards (e.g., USP monographs).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a low-humidity environment to prevent moisture uptake and maintain stability.

Specification

Item	Specification
Appearance	Off-white to pale yellow powder or granules
Identification (IR)	Conforms
Assay (Nicotine Content)	As per customer requirement (typically 2-4%)
Loss on Drying	≤ 5.0%
Residual Solvents	Meets ICH guidelines
Particle Size Distribution	Upon request

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.