Description

5,14,15-Trihydroxy-6,8,10,12,17-Eicosapentaenoic Acid is a specialized, polyhydroxylated derivative of eicosapentaenoic acid (EPA), representing a key intermediate in the lipoxygenase pathway. This compound matters for its role as a bioactive lipid mediator, influencing critical cellular processes in inflammation and resolution. It is primarily needed by researchers and developers in the pharmaceutical and biotechnology sectors for drug discovery, biochemical research, and as a reference standard for analytical studies.

Application

• Biochemical Research Standard: Used as a high-purity reference compound for studying eicosanoid biosynthesis and metabolism.
• Pharmaceutical R&D: Serves as a critical intermediate or lead compound in the development of novel anti-inflammatory and pro-resolving therapeutics.
• Cell Signaling Studies: Employed in vitro and in vivo to investigate the mechanisms of action of specialized pro-resolving mediators (SPMs).
• Analytical Method Development: Acts as a calibration standard for advanced analytical techniques like LC-MS/MS and HPLC in lipidomics.
• Enzymology Studies: Used as a substrate to study the activity and kinetics of lipoxygenase and cytochrome P450 enzymes.

Basic Information

Product Name	5,14,15-Trihydroxy-6,8,10,12,17-Eicosapentaenoic Acid
CAS No.	95851-21-1
Molecular Formula	C₂₀H₃₀O₆
Molecular Weight	366.45 g/mol
Synonyms	5,14,15-TriHETE; 5,14,15-Trihydroxy-6,8,10,12,17-icosapentaenoic acid; 5,14,15-Trihydroxyeicosapentaenoic acid; (6E,8E,10E,12E,17Z)-5,14,15-Trihydroxyicosa-6,8,10,12,17-pentaenoic acid; 5,14,15-Trihydroxy-EPA; 5,14,15-TriHEPE; Lipoxin/Resolvin pathway intermediate
EINECS	Contact for details

Quality Control

Our 5,14,15-Trihydroxy-6,8,10,12,17-Eicosapentaenoic Acid is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods. Our quality commitment aligns with the standards expected for fine chemical and research-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. For long-term storage, solutions should be prepared in appropriate, deoxygenated solvents and kept at -80°C. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95%
Water Content	≤ 1.0% (KF)
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.