Description

23,23-Difluoro-25-Hydroxyvitamin D3 is a fluorinated analog of the biologically active form of vitamin D. This compound is of significant interest in pharmaceutical research and development due to its potential for enhanced metabolic stability and targeted biological activity compared to its non-fluorinated counterpart. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics for conditions related to calcium homeostasis, bone metabolism, and cell differentiation.

Application

• Pharmaceutical Reference Standard: Serves as a critical analytical standard for quality control and method development in the production of vitamin D analogs.
• Active Pharmaceutical Ingredient (API) Intermediate: Used in the synthesis of advanced vitamin D receptor modulators and prodrug candidates.
• Biochemical Research: A key tool for studying the structure-activity relationship (SAR) of vitamin D analogs, particularly the effect of fluorine substitution on receptor binding and metabolic pathways.
• Metabolic Studies: Employed in preclinical research to investigate the pharmacokinetics and pharmacodynamics of fluorinated secosteroids.
• Drug Discovery & Development: A valuable building block in medicinal chemistry programs targeting diseases such as osteoporosis, psoriasis, and secondary hyperparathyroidism.

Basic Information

Product Name	23,23-Difluoro-25-Hydroxyvitamin D3
CAS No.	95826-03-2
Molecular Formula	C₂₇H₄₂F₂O₂
Molecular Weight	436.62 g/mol
Synonyms	1α,25-Dihydroxy-23,23-difluorovitamin D3; (5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1α,3β,25-triol, 23,23-difluoro-; 23,23-Difluoro-1α,25-dihydroxycholecalciferol; 23,23-Difluoro-1α,25-dihydroxyvitamin D3; 23,23-Difluoro-calcitriol analog; 23,23-Difluoro-1,25-(OH)₂D₃
EINECS	Contact for details

Quality Control

Our 23,23-Difluoro-25-Hydroxyvitamin D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere when possible and allowed to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.