Description

n-Heptafluorobutyryl Isobutyl Ester Of γ-Carboxyglutamic Acid is a specialized fluorinated derivative of glutamic acid, designed for advanced analytical and synthetic chemistry applications. This high-purity compound serves as a critical reagent and building block, offering unique properties derived from its heptafluorobutyryl and isobutyl ester functional groups. It is primarily utilized by research institutions, pharmaceutical developers, and analytical laboratories engaged in proteomics, biomarker research, and the synthesis of novel fluorinated molecules.

Application

• Derivatization Agent for GC/MS Analysis: Used to enhance the volatility and detection sensitivity of amino acids, particularly γ-carboxyglutamic acid (Gla), in gas chromatography-mass spectrometry.
• Biomarker Research: Serves as a reference standard or synthetic intermediate in the study of vitamin K-dependent proteins and related biomarkers.
• Proteomics and Metabolomics: Employed in the preparation and analysis of complex biological samples for the identification and quantification of post-translationally modified amino acids.
• Pharmaceutical Intermediate: Acts as a key building block in the synthesis of targeted drug candidates, especially those requiring fluorinated motifs for improved metabolic stability or binding affinity.
• Chemical Biology Probes: Utilized in the development of activity-based probes or labeling reagents to study enzyme function and protein interactions.
• Quality Control Reference Material: Provides a certified standard for analytical method development and validation in regulated laboratory environments.

Basic Information

Product Name	n-Heptafluorobutyryl Isobutyl Ester Of γ-Carboxyglutamic Acid
CAS No.	95654-14-1
Molecular Formula	C15H18F7NO7
Molecular Weight	457.30 g/mol
Synonyms	γ-Carboxyglutamic Acid Heptafluorobutyryl Isobutyl Ester; Gla(HFB-iBu); HFB-iBu-Gla; N-(Heptafluorobutyryl)-γ-carboxyglutamic Acid Isobutyl Ester; Isobutyl N-Heptafluorobutyryl-γ-carboxyglutamate; 4-Carboxy-4-[[(2,2,3,3,4,4,4-heptafluorobutanoyl)amino]pentanedioic Acid 1,5-Diisobutyl Ester; Glutamic Acid, N-Heptafluorobutyryl-γ-carboxy-, Diisobutyl Ester
EINECS	Contact for details

Quality Control

Our production of n-Heptafluorobutyryl Isobutyl Ester Of γ-Carboxyglutamic Acid adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive research applications. All materials are characterized using advanced analytical techniques including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.