Description

Girard's Reagent P is a specialized hydrazine-based derivatization agent, primarily used for the selective isolation and purification of carbonyl compounds, such as ketones and aldehydes. Its unique structure allows for the formation of water-soluble hydrazone complexes, enabling the efficient separation of target molecules from complex mixtures. This reagent is an essential tool for researchers and process chemists in pharmaceutical development, analytical chemistry, and natural product isolation, where precise purification is critical.

Application

• Pharmaceutical Intermediate Purification: Selective extraction and purification of ketone or aldehyde-containing drug intermediates and active pharmaceutical ingredients (APIs).
• Analytical Chemistry: Derivatization agent in HPLC and LC-MS for the detection, identification, and quantification of carbonyl compounds.
• Natural Product Research: Isolation of flavor and fragrance compounds, steroids, terpenoids, and other carbonyl-containing natural products.
• Organic Synthesis: Protecting group for carbonyl functionalities during multi-step synthetic sequences.
• Biomarker Discovery: Tool for metabolomics studies to capture and analyze reactive carbonyl species from biological samples.
• Quality Control Labs: Used in impurity profiling and the purification of reference standards.

Basic Information

Product Name	Girard's Reagent P
CAS No.	1126-58-5
Molecular Formula	C5H14ClN3O
Molecular Weight	167.64 g/mol
Synonyms	1-Carboxymethylpyridinium Chloride Hydrazide; (Carboxymethyl)trimethylammonium Chloride Hydrazide; Girard-P Reagent; Girard's P Reagent; Trimethylammonioacetohydrazide Chloride; Pyridinium, 1-(hydrazinecarbonylmethyl)-, chloride; Acetohydrazide, 2-(trimethylammonio)-, chloride
EINECS	214-415-5

Quality Control

Our Girard's Reagent P is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including assay (by titration), identification (IR), and tests for specific impurities, to ensure it meets high-purity standards suitable for research and industrial use. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (Titration)	≥ 98.0 %
Melting Point	~210-215 °C (dec.)
Loss on Drying	≤ 1.0 %
Residue on Ignition	≤ 0.1 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.