Description

Dansyl-L-Leucine is a high-purity, fluorescent-labeled derivative of the essential amino acid L-leucine. This compound is critical for advanced biochemical research and analytical method development, where precise molecular tagging is required. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic kit manufacturers for applications in fluorescence spectroscopy, protein sequencing, and as a derivatization agent in chromatography.

Application

• Fluorescent Labeling Agent: Used to tag peptides, proteins, and amino acids for detection in fluorescence spectroscopy and microscopy studies.
• Chromatographic Derivatization: Serves as a pre-column or post-column derivatization reagent to enhance the detection sensitivity of amino acids in HPLC and LC-MS analyses.
• Biochemical Research: Employed as a model compound or standard in studying enzyme kinetics, protein-protein interactions, and metabolic pathways.
• Pharmaceutical Analysis: Acts as an internal standard or reference material in the quality control and purity assessment of peptide-based pharmaceuticals.
• Proteomics and Sequencing: Utilized in Edman degradation and other protein/peptide sequencing techniques to facilitate the identification of N-terminal amino acids.
• Diagnostic Reagent Manufacturing: Incorporated into the development of fluorescent assays and diagnostic kits for clinical and research laboratories.

Basic Information

Product Name	Dansyl-L-Leucine
CAS No.	1100-22-7
Molecular Formula	C18H24N2O4S
Molecular Weight	364.46 g/mol
Synonyms	5-(Dimethylamino)naphthalene-1-sulfonyl-L-leucine; L-Leucine, N-[5-(dimethylamino)-1-naphthalenyl]sulfonyl]-; DNS-Leucine; Dansyl-Leu; N-Dansyl-L-leucine; 1-Dimethylaminonaphthalene-5-sulfonyl-L-leucine; N-(1-Dimethylaminonaphthalene-5-sulfonyl)-L-leucine
EINECS	214-156-5

Quality Control

Our Dansyl-L-Leucine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment, to ensure it meets the high standards required for research and analytical applications. A Certificate of Analysis (COA) detailing specific results for identity, purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	Yellow to light brown powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.