Description

(4R)-17-Debromo-2,3-Didehydro-3-Deoxy-4-Hydroxyaplysiatoxin is a structurally defined, high-purity derivative of the natural product aplysiatoxin, a compound of significant interest in biochemical research. This compound matters as a valuable reference standard and a key synthetic intermediate for studying protein kinase C (PKC) modulation and related signal transduction pathways. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on oncology, dermatology, and molecular pharmacology.

Application

• Biochemical Research: Used as a reference standard and tool compound for investigating protein kinase C (PKC) isoforms and their role in cellular signaling.
• Pharmacological Studies: Serves as a key intermediate in the synthesis and structure-activity relationship (SAR) studies of aplysiatoxin analogs for potential therapeutic applications.
• Oncology Research: Employed in studies exploring tumor promotion mechanisms and the development of novel PKC-targeted agents.
• Dermatology Research: Applied in research models to understand inflammatory skin responses and tumor promotion.
• Molecular Probe Development: Utilized in the design and development of specific molecular probes for labeling and tracking PKC activity in cells.
• Academic & Institutional Research: A critical material for universities and research institutes conducting advanced studies in natural product chemistry and cell biology.

Basic Information

Product Name	(4R)-17-Debromo-2,3-Didehydro-3-Deoxy-4-Hydroxyaplysiatoxin
CAS No.	95189-16-5
Molecular Formula	C31H44O9
Molecular Weight	560.68 g/mol
Synonyms	17-Debromoaplysiatoxin; 17-Debromo-2,3-didehydro-3-deoxy-4-hydroxyaplysiatoxin; Debromoaplysiatoxin derivative; Aplysiatoxin analog; PKC activator analog; 4R-Hydroxy-17-debromoaplysiatoxin; 17-Debromo-3-deoxyaplysiatoxin
EINECS	Contact for details

Quality Control

Our (4R)-17-Debromo-2,3-Didehydro-3-Deoxy-4-Hydroxyaplysiatoxin is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profile is provided with every shipment to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation. Keep away from strong acids and bases.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.