Description

Teleocidin B-2 is a potent indole alkaloid and a member of the teleocidin family of protein kinase C (PKC) activators. This compound is a critical research tool for studying cellular signaling pathways, tumor promotion, and neuronal function. It is primarily utilized by researchers and developers in the fields of pharmacology, neuroscience, and oncology for biochemical and cell-based assays.

Application

• Biochemical Research: As a potent activator of Protein Kinase C (PKC) isoforms, used to study signal transduction mechanisms in vitro.
• Cancer Research: Employed in studies investigating tumor promotion and the role of PKC in cell proliferation, differentiation, and apoptosis.
• Neuroscience Studies: Used to examine PKC-mediated processes in neuronal plasticity, neurotransmitter release, and long-term potentiation (LTP).
• Pharmacological Profiling: Serves as a reference standard and tool compound for screening and validating novel PKC inhibitors or modulators.
• Cell Biology Assays: Applied in cell culture models to induce specific cellular responses and study downstream effects of PKC activation.
• Toxicology Studies: Used as a model compound for investigating the mechanisms of non-phorbol ester-type tumor promoters.

Basic Information

Product Name	Teleocidin B-2
CAS No.	95189-05-2
Molecular Formula	C29H41N3O3
Molecular Weight	479.66 g/mol
Synonyms	Teleocidin B II; Lyngbyatoxin B; TL-2; (-)-Teleocidin B-2; 3,12-Didehydro-6-hydroxy-7,22-dioxo-8,20-epoxy-7,20-seco-7,8,20,21-tetradehydro-12,13-seco-lyngbyatoxin A; 12,13-Seco-lyngbyatoxin A 7,20:8,20-diepoxide
EINECS	Contact for details

Quality Control

Our Teleocidin B-2 is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and spectroscopic methods for structural confirmation. A Certificate of Analysis (COA) detailing identity, purity, and assay results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the product to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.