Description

Hbtu CAS NO 94790-37-1 is a high-purity peptide coupling reagent, specifically O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate. This compound is essential for facilitating efficient amide bond formation in solid-phase and solution-phase peptide synthesis, minimizing racemization and improving yields. It is a critical reagent for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences industries developing peptide-based therapeutics, APIs, and novel biomolecules.

Application

• Peptide Synthesis: Primary reagent for coupling amino acids in both solid-phase peptide synthesis (SPPS) and solution-phase methodologies.
• Pharmaceutical Intermediate Manufacturing: Used in the production of active pharmaceutical ingredients (APIs) for peptide drugs, including hormones, antibiotics, and antivirals.
• Bioconjugation: Facilitates the coupling of peptides to carrier proteins, polymers, or other molecules for diagnostic and therapeutic applications.
• Combinatorial Chemistry: Enables high-throughput synthesis of peptide libraries for drug discovery and screening.
• Organic Synthesis: Employed in the synthesis of amides, esters, and other sensitive compounds beyond peptide chemistry where mild conditions are required.
• Academic & Industrial Research: A staple reagent in R&D laboratories for exploring new synthetic pathways and developing novel bioactive compounds.

Basic Information

Product Name	Hbtu
CAS No.	94790-37-1
Molecular Formula	C11H16F6N6OP
Molecular Weight	379.25 g/mol
Synonyms	HBTU; O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; Hexafluorophosphate Benzotriazole Tetramethyl Uronium; 1-[Bis(dimethylamino)methylene]-1H-benzotriazolium 3-oxide hexafluorophosphate; Benzotriazol-1-yl-oxytris(dimethylamino)phosphonium hexafluorophosphate; Coupling Reagent HBTU; 94790-37-1
EINECS	Contact for details

Quality Control

Our Hbtu is manufactured under strict quality management systems to ensure batch-to-batch consistency and high performance. Each lot undergoes comprehensive analytical testing, including HPLC assay, NMR identification, and tests for residual solvents and moisture (KF). We provide full traceability and Certificates of Analysis (COA) are available for every shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and efficacy. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.