Description

Kazusamycin A is a potent ansamycin-class antibiotic and antitumor agent originally isolated from *Streptomyces* species. Its primary value lies in its significant biological activity, particularly as a DNA-binding agent and inhibitor of RNA polymerase, making it a crucial compound for advanced biochemical research. This product is essential for researchers and developers in the pharmaceutical and biotechnology sectors focused on oncology drug discovery, antimicrobial mechanisms, and molecular biology studies.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the discovery and development of novel anticancer and antimicrobial therapeutics.
• Biochemical Mechanism Studies: Used as a specific molecular probe to investigate DNA interaction, transcription inhibition, and cellular apoptosis pathways.
• Antimicrobial Activity Screening: Employed in microbiological assays to study its efficacy against various Gram-positive bacteria and fungi.
• Academic & Institutional Research: Utilized in university and institutional labs for fundamental research in chemical biology, medicinal chemistry, and natural product synthesis.

Basic Information

Product Name	Kazusamycin A
CAS No.	94664-05-8
Molecular Formula	C34H44N2O9
Molecular Weight	624.73 g/mol
Synonyms	Kazusamycin; Antibiotic KA 6643; Ansamycin KA 6643; (3E,5E,7E,9E,11E,13E,15E)-16-[(2R,3S,4S,5S,6R)-4-(Dimethylamino)-3,5-dihydroxy-6-methyloxan-2-yl]oxy-5-ethyl-4,6,8,10,12,14-hexamethyl-17-oxo-1-oxacycloheptadeca-3,5,7,9,11,13,15-heptaene-2-carboxylic acid; 2-Propenoic acid, 3-[8-[(6-deoxy-4-O-(6-deoxy-4-O-[(3E,5E,7E,9E,11E,13E,15E)-5-ethyl-4,6,8,10,12,14-hexamethyl-17-oxo-1-oxacycloheptadeca-3,5,7,9,11,13,15-heptaen-16-yl]-2,3-di-O-methyl-α-L-mannopyranosyl)-2,3-di-O-methyl-α-L-mannopyranosyl]oxy]-5,7-dihydroxy-2-methyl-4-oxo-4H-1-benzopyran-3-yl]-
EINECS	Contact for details

Quality Control

Our Kazusamycin A is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemicals and can provide material suitable for use under GLP (Good Laboratory Practice) conditions.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Long-term storage is recommended at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.